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Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16224-9. Epub 2006 Oct 20.

Yeast mitochondrial ADP/ATP carriers are monomeric in detergents.

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  • 1Dunn Human Nutrition Unit and Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2XY, United Kingdom.


Mitochondrial carriers are believed widely to be homodimers both in the inner membrane of the organelle and in detergents. The dimensions and molecular masses of the detergent and protein-detergent micelles were measured for yeast ADP/ATP carriers in a range of different detergents. The radius of the carrier at the midpoint of the membrane, its average radius, its Stokes' radius, its molecular mass, and its excluded volume were determined. These parameters are consistent with the known structural model of the bovine ADP/ATP carrier and they demonstrate that the yeast mitochondrial ADP/ATP carriers are monomeric in detergents. Therefore, models of substrate transport have to be considered in which the carrier operates as a monomer rather than as a dimer.

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