Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Chem Biol. 2006 Dec;10(6):652-7. Epub 2006 Oct 19.

Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology.

Author information

  • 1Department of Biomedical Engineering, Duke University, Durham, NC 27708-0281, USA. chilkoti@duke.edu

Abstract

Elastin-like polypeptides (ELPs) are artificial polypeptides, derived from Val-Pro-Gly-Xaa-Gly (VPGXG) pentapeptide repeats found in human tropoelastin, that reversibly coacervate above a critical temperature. Genetically encodable ELPs are monodisperse, stimuli responsive, and biocompatible, properties that make them attractive for drug delivery and tissue engineering. The potential of ELPs to self-assemble into nanostructures in response to environmental triggers is another interesting feature of these polypeptides that promises to lead to a host of new applications.

PMID:
17055770
[PubMed - indexed for MEDLINE]
PMCID:
PMC3732176
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk