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Cell. 2006 Oct 20;127(2):265-75.

The regulation of INK4/ARF in cancer and aging.

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  • 1Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, 27599, USA.

Abstract

Loss of the INK4a/ARF/INK4b locus on chromosome 9p21 is among the most frequent cytogenetic events in human cancer. The products of the locus--p15(INK4b), p16(INK4a), and ARF--play widespread and independent roles in tumor suppression. Recent data also suggest that expression of p16(INK4a) induces an age-dependent decrease in the proliferative capacity of certain tissue-specific stem cells and unipotent progenitors. Here, we discuss the regulation and role of p16(INK4a), ARF, and p15(INK4b) in cancer and aging.

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