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Trends Biotechnol. 2006 Dec;24(12):580-6. Epub 2006 Oct 19.

Nanopore sequencing technology: research trends and applications.

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  • 1Departments of Chemical Engineering and Biomedical Engineering, Ann Arbor, MI, 48109, USA.


Nanopore sequencing is one of the most promising technologies being developed as a cheap and fast alternative to the conventional Sanger sequencing method. Protein or synthetic nanopores have been used to detect DNA or RNA molecules. Although none of the technologies to date has shown single-base resolution for de novo DNA sequencing, there have been several reports of alpha-hemolysin protein nanopores being used for basic DNA analyses, and various synthetic nanopores have been fabricated. This review will examine current nanopore sequencing technologies, including recent developments of new applications.

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