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Human leucocyte antigen-C in B chronic lymphocytic leukaemia.
Montes-Ares O,
Moya-Quiles MR,
Montes-Casado M,
Guerra-Pérez N,
Campillo JA,
González C,
López-Bermejo A,
Tamayo M,
Majado MJ,
Parrado A,
Muro M,
Marín L,
Alvarez-López MR.
Department of Immunology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
This study aimed at characterising the distribution of human leucocyte antigen (HLA)-C alleles in a large group of patients with B chronic lymphocytic leukaemia from Southeastern Spain. Ninety-eight adult patients and 194 geographically and ethnically matched controls were studied. HLA-C was determined by polymerase chain reaction sequence-specific primers (PCR-SSP) and PCR-sequence-specific oligonucleotides (SSO) methods. The HLA-Cw*16 allele frequency was found to be significantly increased amongst patients compared with controls in our population (27.6% vs. 12.4%, P = 0.0012, Pc = 0.016). HLA-C dimorphism was also analysed but no association was found.
PMID: 17054674 [PubMed - indexed for MEDLINE]
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