Brain. 1991 Feb;114 ( Pt 1A):333-48.

Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid.

Source

Department of Medicine, Hôtel Dieu Hospital, Montréal, Québec, Canada.

Abstract

A total of 157 epileptic patients were studied with respect to (1) biogenic amine precursors and metabolites in the CSF, (2) levels of folate and thiamine in the blood and CSF, (3) length of treatment with phenytoin (PHT), (4) PHT intoxication, (5) CNS atrophy. Alterations in CSF amine metabolite levels were related primarily to PHT intoxication, and low CSF folate and thiamine levels, but not to length of treatment or CNS atrophy. PHT intoxication increased CSF 5-hydroxyindoleacetic acid (5HIAA). Low folate levels were associated with decreased CSF 5HIAA and homovanillic acid, while low thiamine levels were associated with decreased CSF 5HIAA and 3-methyoxy-4-hydroxyphenylethylene glycol. It remains to be seen to what extent these alterations in biogenic amine metabolism, mediated by low CNS vitamin levels, also lead to deficits in cerebral function.

PMID:: 1705463; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

HighWire Press - PDF

Medical

Epilepsy - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Biogenic amine metabolites and thiamine in cerebrospinal fluid in heredo-degenerative ataxias. [Can J Neurol Sci. 2001]
Biogenic amine metabolites and thiamine in cerebrospinal fluid in heredo-degenerative ataxias.
Botez MI, Young SN. Can J Neurol Sci. 2001 May; 28(2):134-40.
Folate and monoamine metabolism in epilepsy. [J Neurol Sci. 1975]
Folate and monoamine metabolism in epilepsy.
Reynolds EH, Chadwick D, Jenner P, Chanarin I. J Neurol Sci. 1975 Dec; 26(4):605-15.
Cerebrospinal fluid and blood thiamine concentrations in phenytoin-treated epileptics. [Can J Neurol Sci. 1982]
Cerebrospinal fluid and blood thiamine concentrations in phenytoin-treated epileptics.
Botez MI, Joyal C, Maag U, Bachevalier J. Can J Neurol Sci. 1982 Feb; 9(1):37-9.
Review Amine metabolites in the cerebrospinal fluid as a measure of central neurotransmitter function: methodological aspects. [Adv Biochem Psychopharmacol. 1...]
Review Amine metabolites in the cerebrospinal fluid as a measure of central neurotransmitter function: methodological aspects.
Bertilsson L, Asberg M. Adv Biochem Psychopharmacol. 1984; 39:27-34.
Review Genetic studies of CSF monoamine metabolites. [Adv Biochem Psychopharmacol. 1...]
Review Genetic studies of CSF monoamine metabolites.
Sedvall G, Iselius L, Nybäck H, Oreland L, Oxenstierna G, Ross SB, Wiesel FA. Adv Biochem Psychopharmacol. 1984; 39:79-85.

See reviews... See all...

Cited by 3 PubMed Central articles

Folate and depression--a neglected problem. [J Psychiatry Neurosci. 2007]
Folate and depression--a neglected problem.
Young SN. J Psychiatry Neurosci. 2007 Mar; 32(2):80-2.
Review The use of diet and dietary components in the study of factors controlling affect in humans: a review. [J Psychiatry Neurosci. 1993]
Review The use of diet and dietary components in the study of factors controlling affect in humans: a review.
Young SN. J Psychiatry Neurosci. 1993 Nov; 18(5):235-44.
Thiamine status in inherited degenerative ataxias. [J Neurol Neurosurg Psychiatry....]
Thiamine status in inherited degenerative ataxias.
Pedraza OL, Botez MI. J Neurol Neurosurg Psychiatry. 1992 Feb; 55(2):136-7.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Effects of anticonvulsant treatment and low levels of folate and thiamine on ami...
Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid.
Brain. 1991 Feb ;114 ( Pt 1A):333-48.

PubMed
Microsatellite instability and novel mismatch repair gene mutations in northern ...
Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer.
Chin J Dig Dis. 2006 ;7(4):197-205.

PubMed
Urban-rural differences in the management of screen-detected invasive breast can...
Urban-rural differences in the management of screen-detected invasive breast cancer and ductal carcinoma in situ in victoria.
ANZ J Surg. 2006 Nov ;76(11):996-1001.

PubMed
Assessing systems properties of yeast mitochondria through an interaction map of...
Assessing systems properties of yeast mitochondria through an interaction map of the organelle.
PLoS Genet. 2006 Oct 20 ;2(10):e170.

PubMed
Pharmacotherapy augmentation strategies in treatment-resistant anxiety disorders...
Pharmacotherapy augmentation strategies in treatment-resistant anxiety disorders.
Cochrane Database Syst Rev. 2006 Oct 18 ;(4):CD005473.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information