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    Chem Biol. 2006 Oct;13(10):1013-4.

    Enzyme annotation with chemical tools.

    Herman AG, Stockwell BR.

    Source

    Department of Biological Sciences, Columbia University, 614 Fairchild Center, 1212 Amsterdam Avenue, MC 2406, New York, New York 10027, USA.

    Abstract

    Defining the activity of an enzyme in a cell-based system is preferable to in vitro biochemical techniques requiring extensive purification. Chiang et al. use small molecules, RNA interference, and metabolomics to characterize a novel enzyme upregulated in cancer cells.

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    PMID:
    17052604
    [PubMed - indexed for MEDLINE]

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