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Gut. 2006 Nov;55(11):1650-60.

Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease.

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  • 1Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton, Mail point 811, Level D, South Academic Block, Southampton General Hospital, Southampton S016 6YD, UK.


The diagnosis of fibrosis within liver disease is important for prognosis, stratification for treatment, and monitoring of treatment efficacy. The rising incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) has driven the search for accurate non-invasive tools of liver fibrosis within this condition. With the aid of a systematic review, we explore how the field has evolved from the discovery of simple blood parameters to panel markers of liver fibrosis. We will discuss the biological plausibility, limitations, potential uses, and emerging diagnostic techniques of non-invasive markers in this rapidly expanding field.

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