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Immunity. 2006 Oct;25(4):523-5.

Exiting the outside world for cross-presentation.

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  • Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.

Abstract

How are extracellular proteins cross-presented on MHC class I molecules? In this issue of Immunity, demonstrate that the ER-associated degradation (ERAD) export pathway operates in the phagosomes of dendritic cells and transfers antigens into the MHC class I pathway.

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PMID:
17046678
[PubMed - indexed for MEDLINE]
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