Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2006 Dec;29(12):662-70. Epub 2006 Oct 13.

Neurocognitive aging: prior memories hinder new hippocampal encoding.

Author information

  • 1Department of Neuroscience and Neurology, University of Kuopio, Kuopio 70211, Finland. iain.wilson@ed.ac.uk

Abstract

Normal aging is often accompanied by impairments in forming new memories, and studies of aging rodents have revealed structural and functional changes to the hippocampus that might point to the mechanisms behind such memory loss. In this article, we synthesize recent neurobiological and neurophysiological findings into a model of the information-processing circuit of the aging hippocampus. The key point of the model is that small concurrent changes during aging strengthen the auto-associative network of the CA3 subregion at the cost of processing new information coming in from the entorhinal cortex. As a result of such reorganization in aged memory-impaired individuals, information that is already stored would become the dominant pattern of the hippocampus to the detriment of the ability to encode new information.

PMID:
17046075
[PubMed - indexed for MEDLINE]
PMCID:
PMC2614702
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk