Trends Biotechnol. 2006 Dec;24(12):537-8. Epub 2006 Oct 12.

The validity of predicted T-cell epitopes.

Source

Center for Biological Sequence Analysis, BioCentrum, Building 208, Technical University of Denmark, 2800 Lyngby, Denmark. lunde@cbs.dtu.dk

Abstract

High-performing MHC class I binding predictions have been available for more than a decade; however, their value in terms of actual epitope finding has only now been estimated in a large-scale investigation undertaken by the group of Sette. This work underlines the importance of bioinformatics as a resource-saving tool in the field of epitope discovery. In addition, the data can be used to benchmark the performance of other new or existing CTL epitope-prediction tools.

PMID:: 17045685; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Epitopes, T-Lymphocyte

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