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Nat Struct Mol Biol. 2006 Nov;13(11):1026-8. Epub 2006 Oct 15.

Oriented loading of FtsK on KOPS.

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  • 1Laboratoire de Microbiologie et de Génétique Moléculaire, CNRS UMR5100, Toulouse, France.


In Escherichia coli, the ATP-dependent DNA translocase FtsK transports DNA across the site of cell division and activates recombination by the XerCD recombinases at a specific site on the chromosome, dif, to ensure the last stages of chromosome segregation. DNA transport by FtsK is oriented by 8-base-pair asymmetric sequences ('KOPS'). Here we provide evidence that KOPS promote FtsK loading on DNA and that translocation is oriented at this step.

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