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Ann Rheum Dis. 2006 Nov;65 Suppl 3:iii37-40.

Role of nitric oxide in the regulation of T cell functions.

Author information

  • 1Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, UK. F.Liew@clinmed.gla.ac.uk.

Abstract

There is a close relation between T helper (Th) 1 cells and nitric oxide in disease. Thus it is possible that a reciprocal regulatory mechanism exists between them. This paper briefly describes the experimental studies which have helped elucidate the mechanism by which nitric oxide selectively enhances Th 1 cell proliferation and the potential effect of nitric oxide on regulatory T (Treg) cells. On the basis of the results the authors propose that nitric oxide represents an additional signal for the induction of T cell subset response, contributing to the increasingly complex network of immune regulation essential for health and disease.

PMID:
17038470
[PubMed - indexed for MEDLINE]
PMCID:
PMC1798386
Free PMC Article
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