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Org Biomol Chem. 2006 Sep 21;4(18):3517-20. Epub 2006 Aug 10.

Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining.

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  • 1Leibniz-Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11 a, D-07745, Jena, Germany.

Abstract

Motivated by the observation that the Aspergillus nidulans genome bears multiple anthranilic acid synthase gene copies, the fungal metabolome was reinvestigated under various fermentation conditions, resulting in the discovery of novel prenylated quinolin-2-one alkaloids, two of which bear unprecedented terpenoid side chains.

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