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Gynecol Oncol. 2006 Dec;103(3):1164-8. Epub 2006 Oct 10.

Synchronous ovarian granulosa cell tumor and uterine serous carcinoma: a rare association of a high-risk endometrial cancer with anestrogenic ovarian tumor.

Author information

  • 1Department of Pathology, University of California, San Francisco, CA 94143, USA. joseph.rabban@ucsf.edu

Abstract

BACKGROUND:

Ovarian granulosa cell tumors are often associated with endometrial hyperplasia or carcinoma. The endometrial carcinoma is thought to occur under the influence of the estrogen receptor pathway and is typically a low-grade, low-stage endometrioid adenocarcinoma.

CASE:

We present a case of a woman with a granulosa cell tumor of the ovary and a synchronous serous carcinoma of the endometrium. Immunohistochemical stains for estrogen receptors, progesterone receptors, and p53 protein were performed on both tumors.

CONCLUSIONS:

Not all uterine tumors associated with ovarian granulosa cell tumors have low-risk histology. Preoperative evaluation of the uterus with attention to tumor subtyping is important for optimum staging and therapy.

PMID:
17034837
[PubMed - indexed for MEDLINE]
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