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Australas J Dermatol. 2006 Nov;47(4):291-5.

Primary cutaneous diffuse leiomyosarcoma with desmoplasia.

Author information

  • 1Skin and Cancer Foundation Australia, Darlinghurst, New South Wales, Australia. cchoy@scfa.edu.au

Abstract

A 65-year-old man presented with an indurated plaque over his left cheek and left neck. An initial punch biopsy of skin showing increased smooth muscle bundles was consistent with a diagnosis of smooth muscle hamartoma. A second incisional skin biopsy revealed a well-differentiated smooth muscle proliferation invading into the dermis and subcutaneous fat in a diffusely infiltrative pattern and with a desmoplastic component, suggesting a diagnosis of desmoplastic leiomyosarcoma. Resection of the tumour confirmed the presence of a cytologically low grade leiomyosarcoma with an insidious infiltrative growth pattern. This rare pattern of diffuse leiomyosarcoma is important to recognize as the histological features are subtle and may potentially constitute a pitfall in histological diagnosis in a small biopsy specimen. In addition, our case illustrates overlapping morphology between diffuse and desmoplastic types of leiomyosarcoma.

PMID:
17034476
[PubMed - indexed for MEDLINE]
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