J Am Chem Soc. 2006 Oct 18;128(41):13358-9.

A biocompatible method of decorporation: bisphosphonate-modified magnetite nanoparticles to remove uranyl ions from blood.

Wang L, Yang Z, Gao J, Xu K, Gu H, Zhang B, Zhang X, Xu B.

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Departments of Chemistry and Physics, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.

Abstract

We report on the use of bisphosphonate to functionalize Fe3O4 magnetic nanoparticles via dopamine (DA) linkage. Using tetraethyl-3-aminopropane-1,1-bisphosphonate (BP) as the functional molecule, we created a system with an Fe3O4-DA-BP nanostructure, which possesses high specificity for removing uranyl ions from water or blood. This work demonstrates that magnetic nanoparticles, combined with specific receptor-ligand interactions, promise a sensitive and rapid platform for the detection, recovery, and decorporation of metal toxins from biological environment.

PMID:: 17031939; [PubMed - indexed for MEDLINE]

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