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Chromosoma. 2007 Feb;116(1):15-20. Epub 2006 Oct 10.

The role of SUMO in chromosome segregation.

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  • 1Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, E Sussex, UK.


Chromosome segregation is an essential feature of the eukaryotic cell cycle. Efficient chromosome segregation requires the co-ordination of several cellular processes; some of which involve gross rearrangements of the overall structure of the genetic material. Recent advances in the analysis of the role of SUMO (small ubiquitin-like modifier) and in the identification of SUMO-modified targets indicate that sumoylation is likely to have several key roles in regulating chromosome segregation This mini-review summarises the recently published data concerning the role of SUMO in the processes required for efficient chromosome segregation.

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