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Exerc Sport Sci Rev. 2006 Oct;34(4):171-5.

PGC-1alpha gene and physical activity in type 2 diabetes mellitus.

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  • 1Genetic Epidemiology and Clinical Research Group, Institute of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden.


Exercise stimulates PGC-1alpha gene expression and increases V O2max, the latter of which relates inversely with type 2 diabetes risk. Consistently, low levels of PGC-1alpha mRNA and nucleotide sequence variation at PGC-1alpha associate with lower level of V O2max and increased diabetes risk. Thus, PGC-1alpha sequence variation may interact with physical activity to modify diabetes risk via changes in oxidative energy metabolism.

[PubMed - indexed for MEDLINE]
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