Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neurology. 2006 Oct 10;67(7):1268-71.

Effect of donepezil on motor and cognitive function in Huntington disease.

Author information

  • 1Movement Disorders Unit, Neurology Department, Rush University Medical Center, Chicago, IL, USA. estercub@wanadoo.es

Abstract

Striatal cholinergic dysfunction may be important in Huntington disease (HD). We studied whether donepezil improves chorea, cognition, and quality of life (QoL) in HD. Thirty patients were randomly assigned to treatment with donepezil or placebo. At the doses studied, donepezil did not improve chorea, cognition, or QoL. Adverse events were similar between both groups. Based on this small sample study, donepezil was not an effective treatment for HD.

PMID:
17030764
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk