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Neurology. 2006 Oct 10;67(7):1262-4.

Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial.

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  • 1Department of Neurology, Klinikum Grosshadern, Klinikum Grosshadern, University of Munich, Germany.


Mitochondrial dysfunction plays a major role in the pathogenesis of Parkinson disease (PD). Creatine (Cr) is an ergogenic compound that exerts neuroprotective effects in animal models of PD. We conducted a 2-year placebo-controlled randomized clinical trial on the effect of Cr in 60 patients with PD. Cr improved patient mood and led to a smaller dose increase of dopaminergic therapy but had no effect on overall Unified Parkinson's Disease Rating Scale scores or dopamine transporter SPECT.

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