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    Rev Med Interne. 2006 Dec;27(12):927-31. Epub 2006 Jun 28.

    [Is subclinical hypothyroidism a cardiovascular risk factor?].

    [Article in French]
    Schlienger JL, Vinzio S, Grunenberger F, Luca F, Goichot B.

    Source

    Service de médecine interne, CHU de Hautepierre, 67098 Strasbourg cedex, France. jean-louis.schlienger@chru-strasbourg.fr

    Abstract

    OBJECTIVES:

    Subclinical hypothyroidism defined by the presence of elevated TSH levels but normal free T4 level is a common situation. Its consequences on health are yet on debate and the interest of a precocious treatment remains surrounded by controversy.

    KEY POINTS:

    The relationship between subclinical hypothyroidism and cardiovascular disease has been evaluated by several cross-sectional and longitudinal studies. Subclinical hypothyroidism has direct but subtle effects on the heart function, on the peripheral vascular resistance, and is associated with a mild elevation of LDL-cholesterol levels; all abnormalities may be partly reversed by a thyroxine supplementation. Data of the literature give insufficient evidence as to whether subclinical hypothyroidism is an independent cardiovascular risk factor. However treatment of subjects with TSH levels up or near to 10 mU/l would probably be beneficial in the prevention of cardiovascular disease.

    FUTURE PROSPECTS:

    Based on observational and interventional studies there are some arguments on the benefit of euthyroidism restoration only in patients with TSH levels superior to 10 mU/l.

    PMID:
    17030490
    [PubMed - indexed for MEDLINE]

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