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J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Mar 15;848(1):40-7. Epub 2006 Oct 9.

Protein A chromatography for antibody purification.

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  • 1Royal Institute of Technology, Stockholm, Sweden.

Abstract

Staphylococcal protein A (SPA) is one of the first discovered immunoglobulin binding molecules and has been extensively studied during the past decades. Due to its affinity to immunoglobulins, SPA has found widespread use as a tool in the detection and purification of antibodies and the molecule has been further developed to one of the most employed affinity purification systems. Interestingly, a minimized SPA derivative has been constructed and a domain originating from SPA has been improved to withstand the harsh environment employed in industrial purifications. This review will focus on the development of different affinity molecules and matrices for usage in antibody purification.

PMID:
17030158
[PubMed - indexed for MEDLINE]
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