Forensic Sci Int. 2007 Jul 4;169(2-3):152-6. Epub 2006 Oct 9.

Further evidence of in vitro production of gamma-hydroxybutyrate (GHB) in urine samples.

LeBeau MA, Montgomery MA, Morris-Kukoski C, Schaff JE, Deakin A.

Source

Chemistry Unit, FBI Laboratory, Federal Bureau of Investigation, 2501 Investigation Parkway, Quantico, VA 22135, United States. marc.lebeau@ic.fbi.gov

Abstract

This study was designed to supplement previous studies that documented in vitro production of gamma-hydroxybutyrate (GHB) in urine samples. Urine samples were provided by subjects who reported that they had never used GHB (n=31). The specimens were stored under standard conditions of refrigeration (5 degrees C) without any preservatives added. All specimens were repeatedly analyzed for the presence of endogenous GHB over a 6-month period using a previously reported headspace GC-MS method. Significant elevations in GHB were observed in many of the urine samples as storage time increased. As a result, the in vitro production of GHB may increase the apparent GHB concentrations in urine during storage. This potential for an artificial increase in GHB concentration must be appreciated when establishing the threshold between endogenous and exogenous concentrations of GHB.

PMID:: 17030106; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

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In Vitro

MeSH Terms

Substances

Sodium Oxybate

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Chemical compound information

Sodium Oxybate

MW: 104.10 g/mol

MF: C₄H₈O₃

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