Biochim Biophys Acta. 2006 Dec;1763(12):1620-8. Epub 2006 Sep 3.

Peroxisomal matrix protein receptor ubiquitination and recycling.

Source

Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr-Universität Bochum, D-44780 Bochum, Germany.

Abstract

The peroxisomal targeting signal type1 (PTS1) receptor Pex5 is required for the peroxisomal targeting of most matrix proteins. Pex5 recognises target proteins in the cytosol and directs them to the peroxisomal membrane where cargo is released into the matrix, and the receptor shuttles back to the cytosol. Recently, it has become evident that the membrane-bound Pex5 can be modified by mono- and polyubiquitination. This review summarises recent results on Pex5 ubiquitination and on the role of the AAA peroxins Pex1 and Pex6 as dislocases required for the release of Pex5 from the membrane to the cytosol where the receptor is either degraded by proteasomes or made available for another round of protein import into peroxisomes.

PMID:: 17028012; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

PEX1 Gene - Genetics Home Reference

Supplemental Content

Save items

Related citations in PubMed

Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. [Nat Cell Biol. 2005]
Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol.
Platta HW, Grunau S, Rosenkranz K, Girzalsky W, Erdmann R. Nat Cell Biol. 2005 Aug; 7(8):817-22. Epub 2004 Jul 10.
The peroxisome biogenesis factors pex4p, pex22p, pex1p, and pex6p act in the terminal steps of peroxisomal matrix protein import. [Mol Cell Biol. 2000]
The peroxisome biogenesis factors pex4p, pex22p, pex1p, and pex6p act in the terminal steps of peroxisomal matrix protein import.
Collins CS, Kalish JE, Morrell JC, McCaffery JM, Gould SJ. Mol Cell Biol. 2000 Oct; 20(20):7516-26.
Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export. [Mol Cell Biol. 2005]
Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export.
Miyata N, Fujiki Y. Mol Cell Biol. 2005 Dec; 25(24):10822-32.
Review Protein translocation machineries of peroxisomes. [FEBS Lett. 2001]
Review Protein translocation machineries of peroxisomes.
Holroyd C, Erdmann R. FEBS Lett. 2001 Jul 13; 501(1):6-10.
Review The peroxisomal protein import machinery. [FEBS Lett. 2007]
Review The peroxisomal protein import machinery.
Platta HW, Erdmann R. FEBS Lett. 2007 Jun 19; 581(15):2811-9. Epub 2007 Apr 9.

See reviews... See all...

Cited by 7 PubMed Central articles

Peroxisome biogenesis and function. [Arabidopsis Book. 2009]
Peroxisome biogenesis and function.
Kaur N, Reumann S, Hu J. Arabidopsis Book. 2009; 7:e0123. Epub 2009 Sep 11.
Characterization of two common 5' polymorphisms in PEX1 and correlation to survival in PEX1 peroxisome biogenesis disorder patients. [BMC Med Genet. 2011]
Characterization of two common 5' polymorphisms in PEX1 and correlation to survival in PEX1 peroxisome biogenesis disorder patients.
Thoms S, Grønborg S, Rabenau J, Ohlenbusch A, Rosewich H, Gärtner J. BMC Med Genet. 2011 Aug 16; 12:109. Epub 2011 Aug 16.
Dynamic changes in the subcellular distribution of Gpd1p in response to cell stress. [J Biol Chem. 2010]
Dynamic changes in the subcellular distribution of Gpd1p in response to cell stress.
Jung S, Marelli M, Rachubinski RA, Goodlett DR, Aitchison JD. J Biol Chem. 2010 Feb 26; 285(9):6739-49. Epub 2009 Dec 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Peroxisomal matrix protein receptor ubiquitination and recycling.
Peroxisomal matrix protein receptor ubiquitination and recycling.
Biochim Biophys Acta. 2006 Dec ;1763(12):1620-8. Epub 2006 Sep 3 .

PubMed
The neurocognitive bases of human multimodal food perception: consciousness.
The neurocognitive bases of human multimodal food perception: consciousness.
Brain Res Rev. 2007 Feb ;53(2):271-86. Epub 2006 Oct 6 .

PubMed
Corneal epithelial wound healing in the absence of limbal epithelium.
Corneal epithelial wound healing in the absence of limbal epithelium.
Invest Ophthalmol Vis Sci. 1991 Jan ;32(1):96-105.

PubMed
Strategies for reducing maternal mortality: getting on with what works.
Strategies for reducing maternal mortality: getting on with what works.
Lancet. 2006 Oct 7 ;368(9543):1284-99.

PubMed
Interleukins, inflammation, and mechanisms of Alzheimer's disease.
Interleukins, inflammation, and mechanisms of Alzheimer's disease.
Vitam Horm. 2006 ;74:505-30.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: