Molecular orchestration of the hepatic circadian s...[Genome Biol. 2006]

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1: Genome Biol. 2006;7(9):234. Links

Molecular orchestration of the hepatic circadian symphony.

Albrecht U.

Department of Medicine, Division of Biochemistry, University of Fribourg, Rue du Muséee, 1700 Fribourg, Switzerland. urs.albrecht@unifr.ch

The circadian clock determines the rhythmic expression of many different genes throughout a 24-hour period. A recent study investigating the circadian regulation of liver proteins reveals multiple levels of regulation, including transcriptional, post-transcriptional and post-translational mechanisms.

PMID: 17020590 [PubMed - indexed for MEDLINE]

PMCID: PMC1794548

Multiple mechanisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis.
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System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock.
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ReviewSignificance of circadian gene expression in higher plants.
Chronobiol Int. 1996 Nov; 13(5):319-39.

[Chronobiol Int. 1996]
ReviewPosttranscriptional regulation of mammalian circadian clock output.
Cold Spring Harb Symp Quant Biol. 2007; 72:145-56.

[Cold Spring Harb Symp Quant Biol. 2007]
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Cited by 2 PubMed Central articles

Phospholipase C beta 4 in mouse hepatocytes: Rhythmic expression and cellular distribution.
Klein BM, Andrews JB, Bannan BA, Nazario-Toole AE, Jenkins TC, Christensen KD, Oprisan SA, Meyer-Bernstein EL. Comp Hepatol. 2008 Oct 28; 7:8. Epub 2008 Oct 28.

[Comp Hepatol. 2008]
Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators.
Bertolucci C, Cavallari N, Colognesi I, Aguzzi J, Chen Z, Caruso P, Foá A, Tosini G, Bernardi F, Pinotti M. Mol Cell Biol. 2008 May; 28(9):3070-5. Epub 2008 Mar 3.

[Mol Cell Biol. 2008]

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