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Org Lett. 2006 Oct 12;8(21):4771-4.

Total synthesis of topopyrones B and D.

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  • 1Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.

Abstract

[reaction: see text] We describe a straightforward synthesis of topopyrones B and D, which are potent and selective inhibitors of topoisomerase I. The chemistry should be suitable for additional structure-activity relationship (SAR) work.

PMID:
17020299
[PubMed - indexed for MEDLINE]
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