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Org Lett. 2006 Oct 12;8(21):4751-4.

Stereochemical determination of Archazolid A and B, highly potent vacuolar-type ATPase inhibitors from the Myxobacterium Archangium gephyra.

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  • 1Gesellschaft für Biotechnologische Forschung mbH, Medizinische Chemie and Umweltmikrobiologie, Mascheroder Weg 1, D-38124 Braunschweig, Germany.


[structure: see text] The relative and absolute stereochemistry of the structurally unique 24-membered myxobacterial macrolides archazolid A and B, highly potent vacuolar-type ATPase (V-ATPase) inhibitors in vitro and in vivo, was determined on the basis of a combination of extensive high-field NMR studies, including J-based configuration analysis, molecular modeling, and chemical methods.

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