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Cell. 2006 Oct 6;127(1):40-2.

Unwinding a path to nuclear beta-catenin.

Author information

  • 1Program of Neurobiology, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA. xi.he@childrens.harvard.edu

Abstract

In this issue of Cell, Yang et al. (2006b) show that PDGF, a growth factor that induces the transition of epithelial cells to mesenchymal cells, stimulates the c-Abl kinase-dependent phosphorylation of p68 RNA helicase. Phosphorylated p68 dissociates beta-catenin from the Axin destruction complex, thereby promoting nuclear beta-catenin signaling independent of Wnt activation.

PMID:
17018273
[PubMed - indexed for MEDLINE]
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