In recent years the clinical course of celiac disease (CD; gluten enteropathy) has changed. It has been diagnosed more and more frequently in adults. Celiac disease in adults may manifest itself as active, silent, latent and late onset. To confirm the diagnosis of CD the most important is the result of jejunal mucosa biopsy and the presence of anti-endomysium, anti-reticuline and/or anti-tissue transglutaminase IgA antibodies in serum. All the patients with CD should be recommended a gluten free diet. In some cases, resistant to gluten free diet, the immunosuppressive therapy may be taken into consideration.