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J Bacteriol. 2006 Dec;188(24):8655-7. Epub 2006 Sep 29.

Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis.

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  • 1Fachbereich Chemie/Biochemie der Philipps-Universität Marburg, Marburg, Germany.

Abstract

Iron deprivation in bacteria causes the derepression of genes controlled by the ferric uptake regulator (Fur). The present microarray analysis of iron-starved Bacillus subtilis cells grown in minimal medium unveils additional physiological effects on a large number of genes linked to stringent-response regulation and to genes involved in amino acid biosynthesis associated with pathways essential for bacillibactin production.

PMID:
17012385
[PubMed - indexed for MEDLINE]
PMCID:
PMC1698241
Free PMC Article

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