Nature. 1990 Nov 29;348(6300):411-8.

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.

Wang JH, Yan YW, Garrett TP, Liu JH, Rodgers DW, Garlick RL, Tarr GE, Husain Y, Reinherz EL, Harrison SC.

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Harvard University, Department of Biochemistry and Molecular Biology, Cambridge, Massachusetts.

Abstract

The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocompatibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface.

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Immunology. One hand clapping. [Nature. 1990]
Immunology. One hand clapping.Travers P. Nature. 1990 Nov 29; 348(6300):393-4.

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Structures reported by this article

Refinement And Analysis Of The First Two Domains Of Human Cd4

PDB: 3CD4

Source: Homo sapiens

Method: X-Ray Diffraction

Resolution: 2.2 Å

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