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Nature. 1990 Nov 29;348(6300):411-8.

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.

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  • 1Harvard University, Department of Biochemistry and Molecular Biology, Cambridge, Massachusetts.


The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocompatibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface.

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