Philos Trans R Soc Lond B Biol Sci. 2006 Oct 29;361(1474):1777-86; discussion 1786.

Montmorillonite-catalysed formation of RNA oligomers: the possible role of catalysis in the origins of life.

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Department of Chemistry and Chemical Biology and the New York Centre for Studies on the Origins of Life, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. ferrij@rpi.edu

Abstract

Large deposits of montmorillonite are present on the Earth today and it is believed to have been present at the time of the origin of life and has recently been detected on Mars. It is formed by aqueous weathering of volcanic ash. It catalyses the formation of oligomers of RNA that contain monomer units from 2 to 30-50. Oligomers of this length are formed because this catalyst controls the structure of the oligomers formed and does not generate all possible isomers. Evidence of sequence-, regio- and homochiral selectivity in these oligomers has been obtained. Postulates on the role of selective versus specific catalysts on the origins of life are discussed. An introduction to the origin of life is given with an emphasis on reaction conditions based on the recent data obtained from zircons 4.0-4.5Ga.

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