Trends Genet. 2006 Dec;22(12):649-53. Epub 2006 Sep 26.

Know thy mouse.

Source

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

Abstract

In science it is imperative that the basic reagents and materials are defined and uniform. Unlike chemical reagents, which are uniform over time, mice, like all living creatures, have an intrinsic genetic drive to change, with mutations accumulating over time leading to increasing genetic variation and phenotypic change. Such changes compromise the reproducibility of experimental data over time and place. The use of the mouse has expanded rapidly in recent years and many scientists who have turned to the mouse as a research model might be unaware of the profound impact of changes in genetic background. Here we discuss the sources of genetic change and strategies to reduce them with the idea of strengthening international genetic standards for inbred mice.

PMID:: 17007958; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Review Mouse phenome research: implications of genetic background. [ILAR J. 2006]
Review Mouse phenome research: implications of genetic background.
Yoshiki A, Moriwaki K. ILAR J. 2006; 47(2):94-102.
Review Mouse models of human genetic disease: which mouse is more like a man? [Bioessays. 1996]
Review Mouse models of human genetic disease: which mouse is more like a man?
Erickson RP. Bioessays. 1996 Dec; 18(12):993-8.
The evolution of genetic architecture. I. Diversification of genetic backgrounds by genetic drift. [Evolution. 2005]
The evolution of genetic architecture. I. Diversification of genetic backgrounds by genetic drift.
de Brito RA, Pletscher LS, Cheverud JM. Evolution. 2005 Nov; 59(11):2333-42.
Review Quiet mutations in inbred strains of mice. [Trends Mol Med. 2007]
Review Quiet mutations in inbred strains of mice.
Stevens JC, Banks GT, Festing MF, Fisher EM. Trends Mol Med. 2007 Dec; 13(12):512-9. Epub 2007 Nov 5.
Review The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases. [Lab Anim (NY). 2001]
Review The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases.
Linder CC. Lab Anim (NY). 2001 May; 30(5):34-9.

See reviews... See all...

Cited by 13 PubMed Central articles

The C57BL/6J Mouse Strain Background Modifies the Effect of a Mutation in Bcl2l2. [G3 (Bethesda). 2012]
The C57BL/6J Mouse Strain Background Modifies the Effect of a Mutation in Bcl2l2.
Navarro SJ, Trinh T, Lucas CA, Ross AJ, Waymire KG, Macgregor GR. G3 (Bethesda). 2012 Jan; 2(1):99-102. Epub 2012 Jan 1.
Mouse models of prostate cancer. [Prostate Cancer. 2011]
Mouse models of prostate cancer.
Valkenburg KC, Williams BO. Prostate Cancer. 2011; 2011:895238. Epub 2011 Feb 23.
Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice. [PLoS One. 2011]
Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice.
Geurts N, Martens E, Verhenne S, Lays N, Thijs G, Magez S, Cauwe B, Li S, Heremans H, Opdenakker G, et al. PLoS One. 2011; 6(11):e27131. Epub 2011 Nov 11.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Know thy mouse.
Know thy mouse.
Trends Genet. 2006 Dec ;22(12):649-53. Epub 2006 Sep 26 .

PubMed
Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated ap...
Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells.
Life Sci. 2006 Dec 23 ;80(3):205-11. Epub 2006 Sep 6 .

PubMed
Towards a comprehensive analysis of the protein phosphatase 1 interactome in Dro...
Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila.
J Mol Biol. 2006 Nov 24 ;364(2):196-212. Epub 2006 Sep 7 .

PubMed
Structure and expression of the three MHC-linked HSP70 genes.
Structure and expression of the three MHC-linked HSP70 genes.
Immunogenetics. 1990 ;32(4):242-51.

PubMed
Oral antifungal-exacerbated inflammatory flare-up reactions of dermatomycosis : ...
Oral antifungal-exacerbated inflammatory flare-up reactions of dermatomycosis : case reports and review of the literature.
Am J Clin Dermatol. 2006 ;7(5):327-31.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Know thy mouse.

Source

Abstract

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 13 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information