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Antimicrob Agents Chemother. 2006 Oct;50(10):3454-6.

Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli.

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  • 1Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, Uppsala, Sweden.

Abstract

Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the "evolvability of fluoroquinolone resistance" are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under selection pressure.

PMID:
17005830
[PubMed - indexed for MEDLINE]
PMCID:
PMC1610101
Free PMC Article
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