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Bioinformatics. 2006 Dec 1;22(23):2952-4. Epub 2006 Sep 27.

BNArray: an R package for constructing gene regulatory networks from microarray data by using Bayesian network.

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  • 1Department of Bioinformatics Zhejiang University, Hangzhou 310058, China.

Abstract

BNArray is a systemized tool developed in R. It facilitates the construction of gene regulatory networks from DNA microarray data by using Bayesian network. Significant sub-modules of regulatory networks with high confidence are reconstructed by using our extended sub-network mining algorithm of directed graphs. BNArray can handle microarray datasets with missing data. To evaluate the statistical features of generated Bayesian networks, re-sampling procedures are utilized to yield collections of candidate 1st-order network sets for mining dense coherent sub-networks.

AVAILABILITY:

The R package and the supplementary documentation are available at http://www.cls.zju.edu.cn/binfo/BNArray/.

PMID:
17005537
[PubMed - indexed for MEDLINE]
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