Format

Send to:

Choose Destination
See comment in PubMed Commons below
Brief Bioinform. 2007 Mar;8(2):78-87. Epub 2006 Sep 26.

The WWWH of remote homolog detection: the state of the art.

Author information

  • 1Biocomputing Group, Department of Biology, University of Bologna, via Irnerio 42, 40126 Bologna, Italy. piero@biocomp.unibo.it

Abstract

The detection of remote homolog pairs of proteins using computational methods is a pivotal problem in structural bioinformatics, aiming to compute protein folds on the basis of information in the database of known structures. In the last 25 years, several methods have been developed to tackle this problem, based on different approaches including sequence-sequence alignments and/or structure comparison. In this article, we will briefly discuss When, Why, Where and How (WWWH) to perform remote homology search, reviewing some of the most widely adopted computational approaches. The specific aim is highlighting the basic criteria implemented by different research groups and commenting on the status of the art as well as on still-open questions.

PMID:
17003074
[PubMed - indexed for MEDLINE]
Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk