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Med Trop (Mars). 2006 Aug;66(4):343-5.

[Severe opportunistic infections in HIV-positive adults in sub-Saharan Africa].

[Article in French]

Author information

  • 1l'Unité INSERM 593, Université Victor Segalen Bordeaux 2, France. Xavier.Anglaret@isped.u-bordeaux2.fr

Abstract

The threat for opportunistic diseases in HIV-infected adults in sub-Saharan Africa is characterized by a higher frequency of tuberculosis and invasive bacterial diseases than in Europe and by the presence of malaria. Since these three infections may occur early after the onset of immuno-deficiency, HIV-infected patients with less than 200 CD4/mm3 are more likely to develop an infectious episode with severe morbidity in sub-Saharan Africa than in Europe. For this reason the WHO now recommends starting cotrimoxazole prophylaxis at 350 and even 500 CD4/mml in sub-Saharan Africa. The question of whether antiretroviral treatment should also be initiated "earlier" in sub-Saharan Africa than in Europe has also been raised.

PMID:
16999042
[PubMed - indexed for MEDLINE]
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