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Nat Neurosci. 2006 Oct;9(10):1237-9. Epub 2006 Sep 24.

NMDA receptors are critical for unleashing consolidated auditory fear memories.

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  • 1Psychology Department, McGill University, 1205 Dr. Penfield Avenue, Montreal, Quebec H3A 1B1, Canada.


Memories are dynamic and can change when recalled. The process that returns memories to a labile state during remembering is unclear. We found that the presence of NMDA, but not AMPA, receptor antagonists in the amygdala prior to recall prevented the consolidated fear memory from returning to a labile state. These findings suggest that NMDA receptors in the amygdala are critical for transforming a memory from a fixed to a labile state.

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