Cell membrane changes in brains manifesting senile plaques: an immunohistochemical study of GM1 membranous ganglioside

Brain Res. 1990 Jul 2;522(1):152-6. doi: 10.1016/0006-8993(90)91592-5.

Abstract

To investigate structural changes in cell membranes of the Alzheimer-type dementia (ATD) brain, we immunostained for GM1 ganglioside which is a major component of the cell membrane. Our results have shown that astrocytic membranes and senile plaques (SPs) have the same immunoreactivity against the monoclonal anti-ganglioside GM1 antibody. Moreover, the astrocytic processes within the SPs were altered and their abnormal membranes seemed to contribute to the formation of SPs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / pathology*
  • Antibodies, Monoclonal
  • Antibody Specificity
  • Astrocytes / drug effects
  • Astrocytes / ultrastructure
  • Brain / pathology*
  • Cell Membrane / ultrastructure*
  • G(M1) Ganglioside / immunology*
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Staining and Labeling

Substances

  • Antibodies, Monoclonal
  • G(M1) Ganglioside