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J Infect Dis. 2006 Oct 15;194(8):1078-88. Epub 2006 Sep 15.

Low T cell responses to human herpesvirus 8 in patients with AIDS-related and classic Kaposi sarcoma.

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  • 1Laboratoire d'Immunologie Cellulaire et Tissulaire du Pr. Debre, INSERM UMR S 543, Batiment CERVI, Hopital Pitie-Salpetriere, 47 bd de l'hopital, 75013, Paris, France.

Abstract

BACKGROUND:

Kaposi sarcoma (KS) occurs mainly in immunocompromised patients and is strongly associated with infection with human herpesvirus 8 (HHV-8; also known as "KS-associated herpesvirus"). We hypothesized that KS is linked to deficiencies in specific anti-HHV-8 T cell immunity.

METHODS:

We studied asymptomatic HHV-8 carriers coinfected with human immunodeficiency virus (HIV; n = 23) and patients with HIV-related or classic KS (n = 29). We used an interferon- gamma enzyme-linked immunospot assay with 56 specific peptides distributed on 6 HHV-8 proteins (glycoprotein [gp] B, gpH, gp35/37, latent nuclear antigen 1 [LANA-1], K12, and K15) to detect HHV-8-specific T cell responses.

RESULTS:

We found that patients with KS responded to these peptides less often and had much lower HHV-8-specific T cells counts than did asymptomatic HHV-8 carriers (P = .001 and P = .0004, respectively), regardless of CD4 T cell count or HHV-8 load. The frequency of Epstein-Barr virus-specific T cells was similar in both groups.

CONCLUSIONS:

Our results suggest that HIV-related and classic KS are associated with a lack of HHV-8-specific T cells. Also, we have described 8 new HHV-8 T cell epitopes in LANA-1, K12, and K15, including 2 CD4 T cell epitopes. These data provide new insight into HHV-8 cellular immunity.

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PMID:
16991082
[PubMed - indexed for MEDLINE]
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