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    Org Biomol Chem. 2006 Oct 7;4(19):3598-610. Epub 2006 Aug 30.

    The design and synthesis of inhibitors of pantothenate synthetase.

    Tuck KL, Saldanha SA, Birch LM, Smith AG, Abell C.

    Source

    University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW.

    Abstract

    Pantothenate synthetase catalyses the ATP-dependent condensation of D-pantoate and beta-alanine to form pantothenate. Ten analogues of the reaction intermediate pantoyl adenylate, in which the phosphodiester is replaced by either an ester or sulfamoyl group, were designed as potential inhibitors of the enzyme. The esters were all modest competitive inhibitors, the sulfamoyls were more potent, consistent with their closer structural similarity to the pantoyl adenylate intermediate.

    PMID:
    16990935
    [PubMed - indexed for MEDLINE]

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