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Nat Rev Mol Cell Biol. 2006 Oct;7(10):727-38.

The COPII cage: unifying principles of vesicle coat assembly.

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  • 1Department of Electron Microscopy and Molecular Pathology, the Cyprus Institute of Neurology and Genetics, International Airport Avenue #6, Agios Dometios, 1683, Nicosia, Cyprus.


Communication between compartments of the exocytic and endocytic pathways in eukaryotic cells involves transport carriers - vesicles and tubules - that mediate the vectorial movement of cargo. Recent studies of transport-carrier formation in the early secretory pathway have provided new insights into the mechanisms of cargo selection by coat protein complex-II (COPII) adaptor proteins, the construction of cage-protein scaffolds and fission. These studies are beginning to produce a unifying molecular and structural model of coat function in the formation and fission of vesicles and tubules in endomembrane traffic.

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