Nat Rev Mol Cell Biol. 2006 Oct;7(10):713-26.

The ARP2/3 complex: an actin nucleator comes of age.

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Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.

Abstract

The cellular functions of the actin cytoskeleton require precise regulation of both the initiation of actin polymerization and the organization of the resulting filaments. The actin-related protein-2/3 (ARP2/3) complex is a central player in this regulation. A decade of study has begun to shed light on the molecular mechanisms by which this powerful machine controls the polymerization, organization and recycling of actin-filament networks, both in vitro and in the living cell.

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