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Infect Immun. 2006 Oct;74(10):6006-10.

Application of mutated Clostridium difficile toxin A for determination of glucosyltransferase-dependent effects.

Author information

  • 1Institut für Toxikologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Abstract

Mutation of tryptophan-101 in Clostridium difficile toxin A, a 308-kDa glucosyltransferase, resulted in a 50-fold-reduced cytopathic activity in cell culture experiments. The mutant toxin A was characterized and applied to distinguish between glucosyltransferase-dependent and -independent effects with respect to RhoB up-regulation as a cellular stress response.

PMID:
16988280
[PubMed - indexed for MEDLINE]
PMCID:
PMC1594915
Free PMC Article
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