Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Vet Clin North Am Small Anim Pract. 2006 Sep;36(5):975-85, v.

Cytochrome P450 and its role in veterinary drug interactions.

Author information

  • 1Department of Medical Sciences, University of Wisconsin-Madison, School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706-1102, USA. latrepanier@svm.vetmed.wisc.edu

Abstract

Cytochrome P450 (CYP) enzymes are common sites of drug interactions in human beings. Drugs may act as inhibitors or inducers of CYPs, leading to altered clearance of a second drug. Clinically relevant drug interactions involving various CYP isoforms in people, including CYP1A2, CYP2C9, CYP2D6, and CYP3A4, have been well documented. Analogous interactions are beginning to be characterized in dogs, for which canine CYPs share many of the same substrate ranges as in human beings.

PMID:
16984823
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk