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Arch Gynecol Obstet. 2007 Mar;275(3):175-7. Epub 2006 Sep 16.

Evaluation of factors that may be responsible for cyclic change of CA125 levels during menstrual cycle.

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  • 1Department of Obstetrics and Gynecology, Faculty of Medicine, Harran University, 63100 Sanliurfa, Turkey.



To evaluate the factors responsible for fluctuation of CA125 levels during menstrual cycle


The study was performed with patients who had undergone hysterectomy for benign gynecological disease (group I, n = 30) and patients who had undergone laparoscopy for tubal ligation (group II, n = 30) or for investigation of pelvic cause of infertility (group III, n = 24) and showed normal laparoscopic findings. In groups II and III, blood samplings for serum CA125 determination were performed in menstrual and no-menstrual period. In group I, sampling times were determined by using estrogen and progesterone levels. Mean serum CA125 concentrations were compared using one-way analysis of variance (ANOVA) for multiple group comparisons and paired t test for within-group comparisons.


Intra-individual serum CA125 concentrations of group I was not significantly different (P > 0.05). In group II, mean menstrual CA125 concentration was on average 18.2% higher than that of non-menstrual concentration (P < 0.001). Group III showed a similar pattern to that of group II, with a difference of 22% (P < 0.001). Mean CA125 concentration of group I in both menstrual and non-menstrual period was lower than those of groups II and III (P < 0.001). However, there was no significant difference between groups II and III when compared with the corresponding menstrual and non-menstrual CA125 concentrations (P > 0.05).


Endometrium is responsible for the cyclic changes in serum CA125 concentration during menstrual cycle.

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