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1: Nat Rev Genet. 2006 Oct;7(10):812-20.Click here to read Links

Genes, environment and the value of prospective cohort studies.

Manolio TA, Bailey-Wilson JE, Collins FS.

National Human Genome Research Institute, 31 Center Drive, Room 4B09, Bethesda, Maryland 20892-2154, USA. manolio@nih.gov

Case-control studies have many advantages for identifying disease-related genes, but are limited in their ability to detect gene-environment interactions. The prospective cohort design provides a valuable complement to case-control studies. Although it has disadvantages in duration and cost, it has important strengths in characterizing exposures and risk factors before disease onset, which reduces important biases that are common in case-control studies. This and other strengths of prospective cohort studies make them invaluable for understanding gene-environment interactions in complex human disease.

PMID: 16983377 [PubMed - indexed for MEDLINE]