Arch Otolaryngol Head Neck Surg. 2006 Sep;132(9):1009-11.

Antenatal carbimazole and choanal atresia: a new embryopathy.

Source

Department of Otolaryngology, St George's Hospital, Tooting, London, and Department of Genetics, Southampton University Hospital, Southampton, England. Dennis.wolf@gmail.com

Abstract

Carbimazole embryopathy is a recently recognized and defined phenotype. Choanal atresia; gastrointestinal anomalies, particularly esophageal atresia; athelia or hypothelia; developmental delay; hearing loss; aplasia cutis; and dysmorphic facial features all can occur after exposure to the antithyroid drugs carbimazole or methimazole during gestation. Although full expression of this phenotype appears to be an uncommon sequelae of antenatal carbimazole exposure, infants with less overt manifestations may remain with the condition undiagnosed. It is clearly important when an infant with choanal atresia is assessed to take an adequate drug history and consider this embryopathy as a potential causative factor.

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Cited by 1 PubMed Central article

Suspected Spontaneous Reports of Birth Defects in the UK Associated with the Use of Carbimazole and Propylthiouracil in Pregnancy. [J Thyroid Res. 2011]
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