Pharmacogenomics. 2006 Sep;7(6):813-8.

HLA-B locus in Caucasian patients with carbamazepine hypersensitivity.

Alfirevic A, Jorgensen AL, Williamson PR, Chadwick DW, Park BK, Pirmohamed M.

Source

Department of Pharmacology & Therapeutics, The University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.

Abstract

BACKGROUND:

A strong pharmacogenetic association has been reported in Chinese patients between human leukocyte antigen (HLA)-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS).

METHODS:

We have genotyped the HLA-B alleles in 56 Caucasian patients with varying severities of CBZ hypersensitivity and 43 controls on CBZ without adverse effects.

RESULTS:

None of our patients (including two with blistering skin rashes) were positive for the HLA-B*1502 allele. HLA-B*0702 allele may protect against severe CBZ hypersensitivity but warrants further study. Of secondary interest, the correlation between HLA-B*0801 and HLA-DR3, DQ2 and TNF -308 alleles (on the ancestral haplotype 8.1) is consistent with our previous findings.

CONCLUSION:

HLA-B*1502 does not seem to be a marker for all forms of CBZ-induced hypersensitivity in a Caucasian population.

PMID:: 16981842; [PubMed - indexed for MEDLINE]

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